嗯，ok。

um so let's let's begin our meeting。

it's it's an an international uh summit on the uh treatment of my omampatients with resrenal emppoonment ment on chchuh grandanda a foundation。

understday， we we are been honored to have the speaker from the uh。

please the professor milattures。

诶，呃，demo plus。

now he is a professor and chairman of the department of a clinical syerautics at national national uh capppal destroying university of essence。

and visting of the medical school for the academic years。

and also the record of the national and a couple destroy uniververversity of essence for four years and numerous numerous tific societies。

and has ordered more than of seven hundred fifteen publications。

and he will give us speech about a。

about the treatment嗯for the patients。

嗯，with renal impairment uh of motormaroma and offthat uh several propices ses h join our panel discussion。

first of all， professor。

嗯。

长城镇。

嗯，he is a chief physician。

嗯，professor and doctor supervior or post doctors work stations， supervisor of the first， a hospital UUST fessalso。

is a she is a director or kemmotoriage department chief physician udoctorous supervisor of the first people's hospital of changzhou。

and also a professor xu ZHANGLU。

嗯，he is a director of he him mtorage department director of laboratory of himortoriity and a social chief physician， a sociate professor。

of常州number two hospital。

and also a surgeon， he is our doctor asassocichiaf physician of the first， a philial hospital of suso university。

and also me。

呃，全全赋。

i'm from the first a philier hospital of social university。

i'm the chairman woman， ok， let let's begin our。

uh， the first topic嗯，the treatment of newly darnnosed multiple patience with rreninal implement。

let's welcome。

hello， i am professor democruced from the national couple estent and universiity of balsenence， and i'm happy to share with you today。

new data regarding the treatment of movily diagnose patients with my lama who present with an environment。

these are my disclosures。

real impapartment is a common problem in my lama。

it。

it affects up to fifty percent of patients are their nourses。

we know that this complication is usually associated with the worst survival。

the recent international， my normal working group raceria for indian imparta is accrerected interilance of lesson four KML per minute， which can be assessed by either the modification of diet in renal disease， formula or techronic kidniic fordiase ethe diomology collabororation equation。

the recent study indicated。

that that across five european guarantees。

and the percentage of patients who present with some arenal environment is approxitely tely fifty perperent ent us。

even in the recent years， this problem have remain significant for many patients with my my longer。

the puzzle genesis is multifacictorial。

the the primary。

effect is the toxic effect of light chages， and in the the the the tubbuous。

and this is um manmostic cuusally with my laommic dneney or like chaying us mtrophty。

however。

cases， we have either uh the development of familiar yourses or or the development of monochonic ic in loaban deposition disease。

contribute think effects include dehydraation。

hyperkassimia also also the use of knows their roil bet and plplomat of drugs， which is common impatients who have born being without a pride diagnosis of for my lama。

this is。

ST marwiage shows the uh pthoaggenesis of from。

destiny property， we know that that。

free light ges are are feated ther the gloma through the level of proximal to be。

um there is absorsorpof of this， a free lachange howeof。

the proxism is very effective。

then we have the significant reduction of the free light change that go through the distitbo。

however， in several patients， this uh absorb of free light change that go uh activation of the apple doources and damage uh the proximal al oureland， which may link to conclusion of the proximal tubbe。

so this is one inself at the level approachation dube。

they free like chain as they go through the disetuvial。

they tend to bind uh with some whosefile protein and for gusts。

potential driggeons forecast formation include dehildraation administration， philosimiid philossiii contrast agents and also effective agents。

when we have the customer propart ty these leaguers。

very dubillar into ometically reactions。

and at the end you make up。

a inobtraction of the diclt renner to be。

this is uh pictures from like microscopy of patients uh show show typical uh uh uh cast formation at the level of the gluomaal line。

what are the characteristicof for lking？ my lama cusin al property？it accounts for eighty to ninety ccent of seere ing and failure in my lama。

it is important to keeping mind that the protinariia is selected， as you can see here。

uh， you have uh predominance fuffely light chain。

uh， there is a high risk for a good kidney injury。

it may be missed by conventional diicicict st。

at twenty hundred year year， collections should be used for the vivaluation of the the auoria and assessment of the disease。

and in some patients aspect make in the chomonal banand。

this slight shows the diagnostic violation of my lomal patients deacting within an imprent are the agagnosis。

we need to have an assessment of syribratting injury。

assaditive， propasssive culsium calculation of each j phar。

measurement of subtle broadght nature foreases and gimenufixation of exsaplple from a twenty four hour during collection， along with assessment of observver free lghchange。

and if the patient has selective for the ingero， which consised mainly of light change， arenalal biopsy is proably not necessary， but maybe useful inpatients inform。

other conditions are present， such as the rediscppering tepretenence。

if the patient has not selected for the in nororia or sigsignificant argumennororia。

we have to concede their reppresence percomunitive jossises or monocularly uniovelopary deposition disease for other commerciity foundations。

and advance。

usually， we start with a bioacity of a cerpy detrastation for elelector bioity to to erle out compular doorses。

and green er biosit may be often necessary。

it is important to know that if we have a pation with my laoma and reinal environment， but without for the gnororia， an alternative diagnosis of the renal environment should be considered。

these are typical uh uimreortonate pporiisis atterterns， which showthe the seccted broperaunororia， where we have the predominance， uh， uh free lachaine and the not selected with the authoria， which shows and doming ing predominance， and which looks more like syrian broken neporioriis。

regarding the management propatients with acute indian envirment， we have supportive care。

we have mechanical approaches clasmic change for mention humodialysis hykep of humodianalysis and systemic anti， my lma treatment。

supportive care is very important and starts with a appropriate calcuglation of patient ent that we prefer to use vextrrows。

um more a nornoral al sallight， and of course， a yduraation should be combined with antimimate treatment。

we would like to alalcalonize the ururing because this may reuse transformation would like to minance hyperpaenna by first forneetes may be used。

however， you have to take into consideration uh that raza increased risk uh of protrcted tytype casinian imppatients with severe imparonment。

uh， and also today we we have the ausum up， which can be given impatienence human inpaonment。

insome patients are asident everyday senior high deration are maybe enough。

and sytony can be use zero guassims uh h very raradly dly without causing severe hypopensynia and without raisse for femal duxicity。

and of course， the use of珊rumight to to teperacsima is discouraged because it made a generate medium function and increase the formation of casting very interduview。

it is obbuous that we need to avoid never toxic agents， such as norstthe right deelectic ilomatraries。

i'm mean， we like like assignment， bibioics and conprosed addiyes。

the regular什么knovery resasation。

is not successful。

removing the free light change because they have a normlecular waway。

however， in recent years have been several drials s where high cutle of timodialysis filter has been used， which or also a remove uh uh uh such as free light change。

and we have a several facace to stdies and do fahase ory stardies。

我让他给公败了。

啊，the regular conventional himoda liliis， with with high aggo of himodia lisis。

and invove studies， there was no evidence of improved survival impatients uh uh treated with hircut of human dialysis。

uh and VC is an advitional exciiting would shose like a reviation an improvement啊in ner啊the呃。

development to offer humodarialyis ity dedependence， but no difference in the veral survive。

but based on these studies。

at high cuple of human diet， losis figure are not from sevure that stand diver care today for the treatmental patients with my long。

and let's move to systemic to my lama treatment。

yeh， first of all， we have uh to define arena response， which occurs with when reinal impavement is repased by treatment， and we use uh the definition of complete arenal response， parcelonal response and minor arenal response。

and uh， you can see that verversurvival， according during ing function， entries force uh is significant。

several years ago， we published uuh h study， in which we investigated the role nonovnovel agents in the treatment of patients with uh uh my lama and in an department。

we had a group of fashients that erapy。

we had another group of fastitiwhich， which receive ve basbased therapy and group of fastienthat that receisit that that that that the completely that ersithat that higher when on plepleally were used。

furthermore， we have to keep in mind。

that potential， it can be given a four doses inatients could give an environment uh and also it cas。

a very rapid mechanism acction。

this lide shows nonoval agents and the reversibility of indienpavement moved back norse patients with my lama。

and you see that the best results occurred uh with patient studiwith prothesseme and the multivity analysis for factor associated with at least reing。

the part of response included age and the tiof， the age of the patients， lower ger procapability。

uh rehagher， the the g of five of the largic probability。

my lawma response was opposed the dequty factor。

and also use of vertism。

recently， there has been impimpant ant french， french diwith uh uh treated patients with uuh ininpapament， reviver proenefit and uh h， the atizon or pertazation or tamathason， who secular forsome ine VCD is arregiment， which is frequently be used uin。

the treatment of these patients。

this uh did not show any significant benefit。

uh uh HCC ververses。

we be rerenar recovery of patients， which the initial uh uh reninimportment not require uh humodialysis。

你第三第二十个我是啊呃呃。

day suverworworld days are。

to investigate potential proponnostic factors。

and uh， we have shown before they conference， that age is a proagnostic factor preexisting growing。

give me disease is the proagnostic factor。

these patients are the less likely to have have a recovery of interner function。

uh， and also， i could keep the injury。

safethree is an adverfor nosty factor。

and uh， the uh higher， they low wer jfar below the probability to have a complete reversion。

in the ananalyis that we have performed um here， you can see that uh uh the data indicate the patient school had AA hiirer uh free lighing uh concentration had HA lower probability of complete。

we know recovery。

potential， it has shown in several stuties that it is an important variably uh， an important factor to be included in the cheatment papaenence ts， my noromal and environment several years ago。

within within the contevery， the VNP was compared MP to BMP。

we show that VMP was associated with hihighate for reading the recovery as compared to MP。

and the most recent INWG guidelines indicate the protession， in case judgment remain the corestone of the management of formmer in my lama related in an environment。

what does should be started at ststard， those of one point， commitity square， and it is important to give the drug on days， one， four， eight and eleven over three weeks， cycling and high， those methozshould be considered at least for the first month of therapy。

safety， diof and destination impportation， a similar efficcuracy with interbusiness administration， and they are recommended those of ydle。

the temephon is fortunground daily。

they reduce to plint me ground daily for patients over the age of seven， ty five， four days on four days over the first ych le therapy。

and then according uh adjust according to the recovery of humanine function。

in the first i and where patients retreated with some patient and some mephons， there were several enationts with significant renner environment。

and as you can see， uh， there was uh is have volved survioutcome for the patients with severe with environment。

so in this large study would include that many older patients with my lama， it was uh again， demonstrate the adversial impvial uh renal environment uh corperresons with survival into overlow survival， especially when with have severe and environment with the patience ence with a severity。

i also uh patients with severe and environment， then to have then to develop but more often uh muuroopiniia uh， and from iciside opinion than the other patients。

the uh gave my long my eleven side to try al provided to us the opportunity to have a data and uh recently diagnosed patients with indienenrrment and to see there in a outcome。

and as you can see， uh in the two percent of patients， the outcome was unchanged， and it changed in approxunately one first。

and there was a speak uh in about twenty two percent of patients。

uh， there was improvement in sixteen percent of patients。

there was in deteruration。

and coractiisof patient school had imimprovement um you can see here again about the younger age， h。

lower higher EGFR uh uh uh ufaclaties uh uh h。

it was associated uuh higher proporvity for improvement。

other drugs that have been investigated in patients with my loomger given environment include the epace hilinmmid， which was used the uh almost a decade ago as a standard of there。

and more recently。

and we have the new guidelines of the ismal EHA guidelines uh for the hupment of man。

and you can see here about that ignorance。

the jn。

嗯，你。

是吧，a八零。

呃啊呃，你欣那那CA。

c三百巴格BB艾is a。

invasions with uh less advance been been compared。

we have datatabase on recent forounination ation， but investigathe。

比如说我说这个速母慢。

including combinations in the three month to with free ing an environment and might with my lama， for example， in the ascience ddiet。

uh， you can see that that of VMP was better better vaients with a wrappin tems for less than sixty per minute。

similarly， in the media trial， where patients should see the leerally might and the amof of we for without other two forup， we can see。

the presence of environor mostsome jdelines indicate that vertensal baseagereremain the armanma。

high those exammeination should should leleast for for the first mafor therapy。

inatients are algigidly for authoriity sitdiation， but TB could be consider imppatienfor for not to of for for not of enpatilation。

we can use AVMP， but we don't have data regarding patients with severe an environment diditisbut without enditification， but a my disaster sasainpatitience with might to moate a environment， and it should be given with those adjust of to keep mind ind for those therapy， make ervity for an environment。

we can of enitiination。

should be reduced two hundred hundred。

a nice combinations at first line， gitement seem to be affected in my omof patiin the environment， but further seranalyes and are highly anticipated withthat。

i would like up to thank you very much for your kind attention。

thanks much um proices。

and about a drug， the novel， an agis， the in hipit and immit， and he， he give us the and the clclclins BRD and the。

i see you VM in chinese se。

we there when we we have two。

we have four。

discussision fofoperforssers。

professor uh chchgingeng professor xzhangmu and professor uh ongging um if you have some questions or some um ideas， we can talk about with proprossor or promaras。

嗯，professor长城镇。

阿普洛弗沙蓄妆炉。

乳服深松筋。

uh， thank you。

thank you。

i have one。

i have two questions for the professor。

uh。

the first question is， as we know， pleasis as change uusually in in the indication in the situation， it can function in the situation。

yeah， this is a very good question and gives me the opportunity to clarify that。

and you know， these apapaches es， where i mean， gassmic change was started more more than twenty twenty years ago， when the drugs that we had， i were very limited for the treatment of my lama。

so i don't believe that today， there is a law row for blasmic change in patients within an partrent presenting with my lama。

this should be very exceptional。

uh that one may have this indication further more， the the two antimized studies with high cut of human dialysis did not show the significant survival advantage。

and at this point， um this high cut of human dialysis filter are not consider the uh absolutely necessary。

so uh， they may think i mean， as far as mechanical a treatment is falling behind a in view of the more active drugs that we have today uh that we apply to revert uh renal failure。

thank you。

thank you。

嗯，professor徐珍卢呃，if you have any questions。

呃，wait when minutes。

thank you。

i have a quesst a。

the question i have sailed um metocoloo my ommer with the rainimpimpirment。

uh， i want to know if the outcome of these patients。

uh嗯a呃呃。

嗯that the reading implevement is。

呃呃，if association with the process of the嗯，i mean， i mean the the running impimpation with different procedure。

if II underunderood correcrectly， you asking about the prognosis of these patients or。

哦嗯。

阿好，i miss就是嗯。

在在raining啊raining import。

乒乓。

empronment is association with the呃。

嗯，matt my name is speitch。

is if association with the stage of the mttmeloma for， for example，啊。

ISISS teacch uh ok， ok， ok， yeah yeah as you as as you are clearly uh， you know it imply。

ISS stage， which is based on better two microgerplin uh all patients with indian environment。

by definition are SS three。

this is why， because of the increase better better to microglobin， which is seen in reinal failure。

and it is regardless less of the tumor volume。

so this is why i believe are now with the revised diessays。

哎，we can now uh， you know， sort of classify better than patients， many meaning that if you have a patient ISS three by better tomoacro developing， which is got is due to very learly partment。

uh this， this may uh be ISS too。

h。

there is no higher the age inside to genetics。

it is a problem because。

嗯。

we know that better tomicroreloably reflects tumor by tumor lad d of my lama。

but when you have renal impvironment for whatever reason， it is a elevated。

哦，thank you。

嗯，我发射苍城镇。

professant if you have any questions。

呃，郭老师，他去卫健委开会了，等会回来上线。

哦，好好好好的，行的好的，郭老师，我再问个郭老师，我再问题吧，要要不rei， have the in is used。

uh at least at i mean outside proprotable at least for one or two courses。

uh， until we see uh the improvement of final function， because because with with relimate， of course， learly， the might you can use uh， but you come to reduce the those， and you may have ennot predictable uh millow separation。

so in patients with severe and deperation， we prefer to use alternative regigiments。

and also in these patients， we also prefer to use more intensive dexammethoism， especially the defication is young。

we tend to use at least for the first course uh and more intensive dexamethoism approach rather than weekly。

thank you。

thank you。

uh， thank first。

thank you profirst。

i have a question to i ask you。

um we know this disease of umultiple intreatment in the department of dement of uh m terr HMNRR um h uis the multiple， the treatment significance umultimumuuuimpimpment。

um the MGRS。

the treatment of MRS is usually uuh multiple that remm there。

there is any differences um between the RHHMM differ is how h yes， of course， um is is significant difference。

the m is is n diffec rence， the dedifferein the MDRH。

a patient with m gas， otherwise， so meaning minimum buromrereferation low molecular protein， no anyme or no born lesions。

and there are some。

there is a arenal uh impartment， so this condition what's it is called MGRS is very heerogenius。

uh， there are some mentities that can be clearly associated with underlying monocular protein。

uh， but uh， you know。

usually， you need the renal biopc， you need darnala expert pthologies to make the link。

and if you decide that there reasily yes， at this point， you will use regiments that you use uh for my lama， meaning， practising hibit steoid ds。

and uh second， for some might a little might in the future。

there are two momment matter。

but it is uh uh difficult h didificnosis， especially to make the connection because you may have patients with m gas who may have some renal department because of diabetes because of heart failure because of heypertention。

so you need the definitely arenal biopsy to rule out the doses to rule out other conditions to rull out in uniglobal deposition disease。

and then if you can get into this specific rare enabetes with rurusiment the deposition because of deberoate graomitary reforities。

it is rare and difficult to uh conditions to make a diagnosis。

but as you said， if you decide that there is a link， then you take like my lama ah to reduce the production of the free light chain， the ppthat， you have fuuncorality y ing m。

啊，thank you very much。

嗯，in BB for for MG and for。

you're you're absolutely right。

and we don't have uh a lot of data and a lot of data。

ah to support what is the best treatment？。

嗯，好，so they are the rare cases that we see。

we we gave verparasonic taxammetazon， but and sometimes we had seconcular for someone。

thanks嗯，thanks very much。

嗯，we uwe thanks a lot again for proprossssor， give us a wonderful speech um next section。

in the next setion， a。

我以为啊。

i have a case share sharing from professor。

弗诺克因嘤因因在breakfast in阴在。

a show an another case。

thank you， professor go， um， can you hear me？。

um yes， uh， thank you。

thank you for introduction uh so today。

uh first of all， let me share my screen。

thank you for um professor democrats presentation。

and today， the topic i bring here is a uh ritrol stetive study data sharing um the um。

the topic is outloguged stem cell transportation in multiple my leoma patients with renal impavement， a single a santa retrospective study。

i'm uenjoenjoy from himthology department first affiliated hospital to doing worsely um first first ball。

first of all， let's look at the background， we all know that dataset is commcommon complication are commonly， and also on。

i associated with trhier rate of druprelatititicies， reduce ed roworld mortal in the sied patience with on。

i will ofded from other logst stem eltrtransption because of higher rates of drug taxity and transform related mortality。

and also recent studies indicate that transportation eleligible patience with on i who receives ESCTE lonate with compared with those who did not have studies also show that ESCT can be simply carry out in papatience ts mout to moderate or patients on dialassts and aaxof sigsigficantly increased risk of imppatients mortality。

however， these datasets are commonly before twenty sixteen。

so。

we did a rittrospective uh study on our um center data after twenty sixteen。

the contents um will be divided into three parts。

first of all， i would give a brief introduction to ceceduof stem cell mobilization and ASCT in m en patients with i in our then uh， brief introduction of patient screen procedure for this data sharing， and the main part would be the data sharing。

let's take a look at procedures of stem mobilization。

patidites patienwho fulfill induction ererp with intention to SCT without trtrflas m mobdiva m dididil dic CCCCCCFOSSSCSCCCS to to CC。

if papas SC lus is tween， thirty GCSSGCSS and GCSFFCCSFFTE ef FTESSCSSSCD for blood is over ten。

half， as this target is city city， four over ten times， take ten two times tend to the sixth per kilogram for one transport， ant at least。

and if two transplants consider the collecting number should be over four。

um as for the procedures of ASC， first， first， all， let me introduce the conditioning， although melelis the standard conditional rerement all over the world， but this rug， g， not TTTTT always get melrogram。

and also it is always get expensive is tween between ty ty ATELTTT eeet OMM is drug between ty ty， ty ty ty AA elpht mmicrogram to expensim to six hours。

from day minus seven to minus four and CTX one point， a gramp of square meter daily from day， minus three to minus two。

and if a patient chese melelfelin， all the patient had to is melelfelin if the create nuclearance is between thirty and sixty with melone thirty forty sixis seventeen microgramp square metre from day。

third to seconsecond day before transform。

and if is one hundred malone， one and malone sevenmmicrogram s rem d day on on t ininten and profsefision on day zero。

and as for paspent， tive caare， part defety to madeand and and pproproffixis should done one， if papatience to given ven。

if the plplent is is s fein facactert SR ininrus inr t infection prothe sixis be done one。

if the patient is dependent of xxis should be done。

and if the patient is in prepression period and can not on day CRT instead。

so next， let's take a brief look。

this uh patient screening procedure in this study。

first of all， with some up all the patients um m patitients cept t stestem ell in fusion between july， twenty sixteen to september， twenty， twenty one。

the number is three hundred and sevennine， and we want to study twenty patience。

narah juate inference below sixty fifty six eteen to two objuve pluluone hundred pai， NN sepmber， twenty twenty paand and to join twenty twenty one and also。

standard transfer uh in transportation， tation uh is discussed here only so the city thirty voys um above two。

so finally， thirty four cases slept the ROO uh single transforort。

so next， we uh is the data sharing um part， and the old is quite common。

a common olum patient characteristicics induction are be evaluation after induction condition marangment in roupman adverse events。

uh evaluation of the transspoundation consolidation maintenance and survival。

so first sovel， the patient capacistics at diagnosis uh， for the gender part mail， uh， fifty six percent female， forty four percent meeting age at SCT fifty five years old， the ranangis forty two to sixty eight years old， tipe， um we noce， ce， the lilighting type and double cloans type， um has a higher rate um。

twenty four percent of carver， twenty four percent of lum， down twenty one percent of double loans。

and for the DS in IS stage， the patients were many in the third stage um occupy like above nineteen percent ufor。

the r alf pastage half uh almost half patient， half， another half patient fifty to fifty two percent stage。

three。

and we also um calculted the um h eighppertifor， eighty perpercent is perpertive conbe found um um ty perperperperperent sixty percent。

ranrange is ten perperperpercent is the sixty perpercis is sixty。

two percent is high， risk， and thirty eight percent is missing， and seventy， ten， checked or information missing another exa AMLLLMMS cs， ty， ty， ty， perpercent and percty is conperum。

uh， almost half of the patient is positive in at least one side。

congo rrestining， which is above our expectaation。

swish notice this in transportation。

and for the reno um fununction part meeting， meeting， incurrence is eighteen point forty nine， the meeting， twenty four um proproting， a two fifty and and the cancer papaent dependent on chemo dialasis AAAAAAS sid， a didi CO vision。

and for they come up， but the commovilities， the most common one is hypertension。

and also， we a kindininfunction h yperfefection also tubo and breast cancer history。

for the induction， all patients accept ausmmer based induction therapies like VRDVTDVCD， and one patient had VR two six point nine percent， ent had than one speciind EVD of ererp and and VVOCRP， um they have combination of induction therapies。

after the induction， we did a evaluation， we did a complete remission， twenty eight percent。

and one patient had seventy MRD next tivty， forty eight percent， dehieve MRD dialvuum lelevel ten to diyasuh patient create um creating ting clearand。

and RD inccrease to seventy thirty seven point， six， six two and the patient ty ty dedease to indetity ty uthe um patient dependent on himo dialoxis decrease to twelve percent， only four patient dependent on himmdalalasses。

the meeting to m mmodalasis uh independence moord four independence eighty seven days， uh patient ten to mdepercent。

嗯days and the renal response嗯come嗯for patient。

got complete remission and two patient got partial remission， sixty patient go minor呃，response um an eleven patient instead uh is in in in the same uh in the same face， and one patient have missing data。

uh， next in stem cell mobilizzpart， um as i have introduce in introduced before， uh， we use three kinds of mobilization method according to the craatent cleclerence and h range is ty ty。

four percs everress s mulerarplus GCSF。

uh left use GCSF or pleric safa number of five perresses most of people six to two percent。

uh， two f arresses and twenty nine percent， two aprresses and nine percent use three apverresses number two city， thirty four count and three ruh。

uh， seventy nineteen， four， fifty eight， and the range is two to sixteen。

uh， before transform， we did another evaluation， and we notice that the patient three more patient in p ds。

uh in progress disease， which mean uh with renal defunction tend to progress easily on this stage um creatating clearrence ces almost the same thirty thirty five。

uh， there are people papatient on alalxces。

and the uh still four ectwo eco ecceone thirty five。

uh， and then the uh conditioning regiment， we use beside or melelelas as i inroroduce before and should be noticce not there is only one patient is um only do someone ince。

the patient has commobity so PFOPNAL。

and she can't afford melelent。

so we use BU alone。

and also， we have a patient you smell to hundred since according to the instruction of melelland。

uh。

the those uldn't we can use a mail to hundred hundred in the patient with reno， diis function。

and this patient has a city sorory for more than ten。

so we use malt to a ll us a lesson live this upwards。

and the uh thirty thirty four ouring fees， the meeting range is three point forty one from two to ten and also the blood product transfusion um since they um blood product is limted here in china， we use only um HHB less than sixty perperson uum red blood cells， so only fifteen percent for the red blood cell transfusion and all the patient to entransfusion the meeting in time to enropment for nenetrfufeel in ten days。

for platlet is twelve days， and we have one patient。

um with graph failure， it's a secondary graph failure。

the patient is um uh had in encouravement of planate。

but after one to two months of the transportation， the patient is back to plant transfusion on status is only this afterwards to discuss。

and now we a look at the adverse events we notice that as literally reported， papatient has uh the patients have higher rate of um gragififty system digestive system like adverse evenent like disivsystem， um for the GI bleeding patient has um exgreat one to drive bleeding， and five patient have um great， great transanenance increase and patient didisisireate。

and for the eronor system， half ful papatient seventeen， exact fifty leadadtrexinse increase have they finally recovered？。

seventeen percent fifty um h seventeen patient， fifty perperchioney etropicnic fever， and most of them can be found the infection side。

only one patient cannot uh the infection side as am found。

and for the infection， fifty three percent having infection。

uh， the infection sites are various oral cavity。

paraninal rgiing GI track afternoon uperatspiratory track。

line blusstream caceder and six six patients have compound infection， and two have infective shock。

for the cardiovascular system， fifty percent have cardioascue adversities， including hypertension or race， meere and hot failure。

and one patient to illusion in the neurropsychiatric system on the complications include ss TOSHBV activation and msyndrome。

one TR ropsypaperent ent made id to ICU um because of severe infection， and one TRM person is three percent。

after the uh transportation with did another uh evaluation， and the SCR percentage goes up to fifty percent， and no patients in PD um MR ty neacvvuum two levels， ten， two minus four and ten， two minus six were checked uten ten minminfour uh， the ten two percent negative and in the ten to minus six， seventy three percent negative uh um uum creatating ing currents， forty almost most the same um as the um baselbefore trtrsportation。

so although patient and in the eighty injury during the transportation， uh， it recover and still four percent dependence uh himo dialoxis。

the reno response is almost the same um as before the transportation。

so let's do uh little summary here。

there are many data uh。

we can see relatively high rate of microsidies and infection during the transportation， and also also relavevhigh rate of a cute trenor implement， but finally recover。

and also the cordect events not and common， which should cause our history and also a secondary growth failure。

and the possible reasons i listed here。

first of all， the patient had uh is was way the MF two after induction。

uh， she also a secontient high brory also accept a rosis and sorry， and also the patient has a breast cancer history。

um although the patient， the retion condidireriment doses mell one er not very high uh uh， and also she accept a repeat direct stem cell infusion five months later。

she is still dependent on plant transspsion sion， the possipossireason perhaps MF two， and also the breast cancer treatment history leads to have a melervability of the own marrow is um not very good， but um we have one TRM here。

the patient dial of new monia。

um um this is the only patient mmt to hundred since。

so ah she had a melt in synroamt uh over ten， but also during the transformation， the patient develop a severe in grment syndrome。

so um this um give us that lessent melt to hundred should be carefully consider。

um we we d better to vovoid using this sesearch also also contcontrol the amount of city three four。

uh also also eefficacy summary as i mention before before transportation， three more patient in progressive disease， which means perhaps the patient with renal。

this function tend to progress easily at a stage， and also， after transportation efficacy is inlaget get even better or response。

and for the MRD part， the before uafter induction before transpountation， almost a fifty percent negative。

and after that， eighty five percent and also there is a high percent of MRT netivity uh on the ten to minus six level。

and for the renal efficacy， i also did a try to compare。

we can see that。

uh， the basase al preattening is patient after induction， thirty six， and after transportation， three nine， these or the average data。

so we can see here um the maen improvement of reno function is in the induction stage， and the inansfortion tation is not get tting worse and will consolidate the effect， but also will not improve it effect。

but also， we can see here um the patient get riof himodalasses， uh transansstage。

and after induction， the patient numal patients get rid of himdaloasses。

so uh， let's move on to a brief introduction of consolaation and and intenance the patients。

um the consullation part， the patient had a repeat inductions therapy before two cycles， and three patients accepted first mten them patience acacact d second therapin clinical trial， no patients accepted second transportation and maintenance， according to the risk tradification。

uh did a brave summary of the survival。

uh， meeting follow up time after transportation is foreign point one minth。

the ranges one point six to sixty one point four， the estimamedium PFS from transportation and meeting one point eight month and meeting OS from diagnosis not reached yet。

uh so a little discussion here are。

for the experience， part， SCT still feasible and effective in m patients with RI。

and but a relatively higher rate of AE， compare with m patients with normal renal function， and we can refor dision during the transfountation。

and also， m patients with induum tend to progress in a stage， and CT will consolidate the effeccy induduction inimimprovement occurcurin induction tion， atand and CT consolidate the effect。

and for the lessons part， make careful about sion during the transsper ful patients with secondary MF to especially for this with cancer treatment evenory and be careful about the very condiment。

and and conense a very high count and in we of concleal syddrome and didition atment and for the future。

uh， we need further data， and we need how to。

optimize the process in the reduce DAE。

that's all for today。

uh， thank you for your tiof attention。

thank you。

啊。

ok， let's呃。

let's have the second topic um so in do you have any uh questions ask for uh doctor timer blues？。

uh， thank you for uh。

thank you professor um professor demopilis。

i i've got a one question associated with my topic， um h can inintroduce your experience uh transportation for patients with um renal dispfunction。

thank you。

first over， i would like it to thank very much professor or yyuum for this excellent， uh data collection， analysis and presentation。

and i hope that this should be published soon soon in sesuous general because as we know， uh these data on patients with patience， ts and dselatbefore before lammuuh remain in frequent。

we do not have such an extensive experience。

uh h。

patience ence， my lammuh undergoing hydos in the parties。

and but also professors， i agrees with what professors i presented h redatthat。

we from the literature， meaning that we know that this patience are at the risk are a complications for societies ties。

also， that may be more millittle operation， and it is also important to agrees with what heyssmmepresprested h agrewith a hyto s is that in in the future。

and as we develop more effective regiments for induction of my lama， and we have the more widespread availability experience with minimal resigial disease assessment。

it is， you know that it is duction。

we will be able to identify with patineactissment。

it is believe that among these patients and with lect arperuuh be treated with patitiment would collect stem csessor and to using the future。

uh， to avoid this uh be treated with it is possisee。

i believe that hydose therp remains any important treatment for my lama uh when did not have other other options twenty years ago， uh several patients even with reiniconment went through hydo's meiphon。

but i believe that this indication will be more restricted even urereuh。

according to basation selection in the future。

thank you。

i don't know what you think about that。

thank you， professor。

so。

professors say。

do you have any other openings about that？。

well， i think um professor mobile has has given a very good opinion that since we have many uh um searity choices nowadays， with transportation， the uh positional transportation should be discussed in um patients with renal disfunction and perhaps next to al and um clinical trials compcomppaways with um transpountation and with noble drugs， um maybe this is a new point。

ok， let's uh the our work will down the next year。

so oh， let's work other uh professors professor。

ok喂。

uh thank you very HI。

have a question。

嗯，i well II um thank you for your question。

uh， first of all， will divided the transfountation into two phases。

the first one is the patient has relatively normal um bloocell count， and they can do the uh regular dialysis um， which means they can dialosses um， we do the dialyxis and zone and do the dalyasses。

and so we can arrange the the order。

and first， we do the dialasses。

and then we is diyasses。

and first， we to today normanother um aloasses。

and then when in the bommard depressed sion suppression period like the whblosalls ses ses， and though， and dependent on transfusion will change to the CRRT bedsite and invite the dialasses uby bedsite。

and then uh after um in graasfment。

and the patient came back to normal。

嗯，thank you very much。

professor thank thank for professor day。

i have two question。

one questions once not show that the patients before transportation， the MID pertititience， uh， i can MID negative patient is so high。

i want to know uh， which achment the indutienments you used in all this patients。

the other question is h， which quesknow the neinning permanent patients。

uh。

could get the stemocell transportation can improve the PFS and OS udo you compared the urunning empmpire patients with the normal uh running ficction patients啊。

thank you。

uh， thank you professor for your questions。

uh， for the first one， the uh induction um erapapum II didn't um do the statistics， according to the uh neactivity of the MRD um h， just in total calculation in total tal m。

so many um many species of induction therapy um VRDVTDVCD and PADPDD。

all of these um patients are in use， but according to our previous um um previous quesence um HD to get a better response dithis response after the induction therapy， but VTD um tend to have a better renal response during the induction， um h perid d that's the experience。

and we haven't do the statistics up to now um for the second question， um since time is limit。

did h。

since i was given this tart task， so i didn't do a comparative comparison with the patience with normal um reno function。

and after this， maybe II can do focus on uh patience with on。

i only。

先屏了。

小k so阿doctor松奇。

啊，就听不到嗯。

please open your microphone。

nowadays， very usually efununthan。

they can see that。

they they they that what is the mobilizdifferent strategy。

a center for the different passions with different randoof function。

thank you。

uh， thank you， professor。

uh for your question for the uh mobilize strategy um commonly。

it is according to the uh experience， all the habx of each， but but in the mmininenuse GCSS， but not reasfor， the patient with renrendifununction， but uunormal reinffection can increasase the CTX plus GCSS when the patient um cannot get enough stem self， but the uh GCSF only a strategy because the CTX infeaccan um incincase ase adversicbut also uh infection because the most of the ffection。

but can our center？ you know that our habit or experience is to use the CTX plus GCSF to get a better uh。

result， uh， we tend to use this in the um patients with concreatining clerenance above thirty， which h they can still use CTX and blow city we use to CSS for long。

thank you。

一神宁啊。

啊，这个讲以讲啊嗯嗯。

讲好了。

k， is there any questions so uh？。

嗯，it's is uh today。

we have a great um summit and many uh uh many famous professes keep on uh data嗯and the experience with嗯how to deal with the patients with患者的一个肾功能不全的一分析析，那特别是是很的教授啊。

他们也问了很多的不同的问题，也就是如何能够解决这些患者的一个情况，how to colcollect stemself。

and how to give different different different不同的计量and ortbecause。

so um i think uh today's uh a meeting， today's lecture is very important。

and maybe we have in next time。

uh III just want to know doctor democplus， will you go to ash meeting？ uh this year？。

sorry， your microphace is close。

i i'm planning to go to rush。

okay。

because you know， uh， maybe before the next year， march， we h we， we， if we go outfor。

uh， uh outside the china， we have to be isolated for more than uh thinof three weeks in china。

so yeah， yeah， yeah。

so we just uh yeah， maybe we just uh on on online to atend end meeting online。

so ubut， but do you have any electures on arh meeting doctor？。

demcrlus。

and i have no， i have a poster。

i don't have an order presentation this year。

okay， ok， ok。

uh i have also i have posters about。

i think it's about carty。

yeah ooyeah yeah yeah online。

i think。

yes， ok。

so thank you very much professor food and professor or tie and proprofessor and colleagues。

uh for this。

uh interactive meeting ouh。

i believe that you， you know， this gives us the opportunity to have a frequent exchange of opinions and h。

ay for the treatment of my lama。

thank thank thank thank thank proprossssor kk。

thank thank for everyone。

what tending is meeting。

and thank you。

bbye bye yebye see you next time yebye bye。

可k。